| COS Unique Id: |
113358 |
| Title: |
FDA Small Scientific Conference Program (R13/U13) |
| Sponsor: |
Department of Health and Human Services (HHS)
Food and Drug Administration (FDA)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
July 15, 2008 October 15, 2008 January 15, 2009 April 15, 2009
|
| Deadline Note: |
The opening date is May 1, 2008. This opportunity will expire on July 16, 2011.
For
some conference grant applications, the time from submission to funding
is shorter than the regular cycle. A second level of review by a board
or council is not required for applications with budgets less than
$50,000 total costs; therefore, funding selections may be made sooner
than the cycle indicated.
Applicants may submit more than one
application, provided they propose scientifically distinct conferences
or scientific meetings. FDA centers will not accept multiple
applications for a single scientific meeting.
Advance
permission to submit an application must be requested early in the
process and no later than six weeks before the application submission
date.
Most centers will accept applications for up to five years
when a series of annual or biannual meetings is proposed by a
permanently sponsoring organization. Support for meetings held on a
less frequent schedule must be applied for individually. |
| Amount Note: |
This FOA will use the FDA conference grant
(R13/U13) award mechanism. The FDA U13 is a cooperative agreement award
mechanism. Because the nature and scope of the proposed activities will
vary from application to application, it is anticipated that the size
and duration of each award will also vary. The total project period for
an application requesting support may not exceed five years.
This program does not require cost sharing. |
| Eligibility: |
Eligible organizations include for-profit and
nonprofit organizations; public or private institutions, such as
universities, colleges, hospitals, and laboratories; units of state and
local governments; eligible agencies of the federal government;
domestic institutions and organizations; and faith-based or
community-based organizations.
Foreign institutions are not
eligible to apply for conference grant support. An international
conference can be supported through the U.S. representative
organization of an established international scientific or professional
society. |
| Citizenship or Residency: |
United States
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Ph.D./M.D./Other Professional Commercial Government Nonprofit Academic Institution
|
| Abstract: |
The FDA recognizes the value of supporting high
quality conferences and scientific meetings that are relevant to its
scientific mission and to the public health.
A conference or
scientific meeting is defined as a gathering, symposium, seminar,
scientific meeting, workshop, or any other organized, formal meeting
where persons assemble to coordinate, exchange, and disseminate
information or to explore or clarify a defined subject, problem, or
area of knowledge. Support of such meetings is contingent on the fiscal
and programmatic interests and priorities of the individual centers,
which are linked to the FDA Grant website (http://www.fda.gov/).
Therefore, a conference grant application is required to contain a
letter from the appropriate FDA staff documenting advance permission.
Investigators are urged to initiate contact well in advance of the
application receipt date. Agreement to accept an application does not
guarantee funding. |
| Contact Name: |
Michelle Hawley, Acting Team Leader |
| Contact Address: |
Grants and Assistance Agreements Team Division of Acquisition Support and Grants |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 827-1991 |
| Contact Email: |
Michelle.Hawley@fda.hhs.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/rfa-files/RFA-FD-08-003.html |
| Date Last Revised: |
April 9, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113358 |
| Keywords: |
Agriculture and Food Sciences
Energy Sciences
Engineering
Natural and Physical Sciences, Mathematics and Technology
|
| Sponsor Reference No: |
RFA-FD-08-003 |
| Funding Type: |
Collaboration or Cooperative Agreement
Meeting or Conference or Seminar
|
| COS Unique Id: |
113372 |
| Title: |
Genetic Screens to Enhance Zebrafish Research (R01) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
September 24, 2008 September 24, 2009 September 24, 2010
|
| Deadline Note: |
The opening date is August 24, 2008. Non-required
letters of intent are due August 25, 2008; August 25, 2009; and August
25, 2010. This opportunity will expire on September 25, 2010.
An
individual principal investigator may submit only one application per
year in response to this announcement. There is no limit to the number
of different applications that an applicant institution may submit. |
| Amount Note: |
This FOA will utilize the NIH Research Project
Grant (R01) grant mechanism. Budgets for under $500,000 direct costs
per year and project duration of up to five years may be requested.
There is no special set aside of funds for applications submitted in
response to this announcement.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include institutions of higher
education; nonprofits, for-profits, and small businesses; state and
local governments; eligible agencies of the federal government; and
non-domestic organizations. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Ph.D./M.D./Other Professional Commercial Government Nonprofit Academic Institution
|
| Abstract: |
This FOA encourages investigator-initiated
applications designed to exploit the power of the zebrafish as a
vertebrate model for biomedical and behavioral research.
Applications
proposing to develop new genetic screens of high priority to the
zebrafish community that will advance the detection and
characterization of genes, pathways, and phenotypes of interest in
development and aging, organ formation, neural processes, behavior,
sensory processes, physiological processes, and disease processes are
welcome.
Proposals responsive to this FOA will include, but are not limited to, the following: 1.
The development and/or application of novel screens for mutants - These
may be refinements of phenotypic analyses preparatory to screening, or
phenotypic screens based on observations of altered morphology,
physiology, or behavior. 2. Screens identifying novel developmental
genes and pathways, including those mediating sensitivity or resistance
to environmental teratogens 3. Screens identifying genetic modifiers of genes and/or gene variants affecting pathways of interest 4.
Screens analyzing the genetic basis of adult phenotypes including
behavior, aging, organ disease, cancer, and responses to environmental
toxicants, alcohol, and drugs of abuse 5. Development of high throughput small molecule screens (including nanomaterials)
Participating
organizations include Eunice Kennedy Shriver National Institute of
Child Health and Human Development (NICHD), National Cancer Institute
(NCI), National Heart, Lung, and Blood Institute (NHLBI), National
Institute on Aging (NIA), National Institute on Alcohol Abuse and
Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal
and Skin Diseases (NIAMS), National Institute on Deafness and Other
communication Disorders (NIDCD), National Institute of Dental and
Craniofacial Research (NIDCR), National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK), National Institute on Drug Abuse
(NIDA), National Institute of Environmental Health Sciences (NIEHS),
National Institute of Mental Health (NIMH), and National Institute of
Neurological Disorders and Stroke (NINDS). |
| Contact Name: |
Dr. Lorette Javois |
| Contact Address: |
Center for Developmental Biology and Perinatal Medicine, NICHD 6100 Executive Boulevard, Room 4B01, MSC 7510 |
| Contact City: |
Bethesda |
| Contact State: |
Maryland |
| Contact Zip: |
20892-7510 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 496-5541 |
| Contact Fax: |
+1 (301) 480-0303 |
| Contact Email: |
lj89j@nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PAR-08-138.html |
| Date Last Revised: |
April 9, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113372 |
| Keywords: |
Animal Models
|
| Sponsor Reference No: |
PAR-08-138 |
| Funding Type: |
Research
|
| COS Unique Id: |
113373 |
| Title: |
Enhancing Zebrafish Research with Research Tools and Techniques (R01) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
September 17, 2008 September 17, 2009 September 17, 2010
|
| Deadline Note: |
The opening date is August 17, 2008. Non-required
letters of intent are due August 17, 2008; August 17, 2009; and August
17, 2010. This opportunity will expire on September 18, 2010.
An
individual principal investigator may submit only one application per
year in response to this announcement. There is no limit to the number
of different applications that an applicant institution may submit. |
| Amount Note: |
This FOA will utilize the NIH Research Project
Grant (R01) grant mechanism. Budgets for under $500,000 direct costs
per year and project duration of up to five years may be requested.
There is no special set aside of funds for applications submitted in
response to this announcement.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include institutions of higher
education; nonprofits, for-profits, and small businesses; state and
local governments; eligible agencies of the federal government; and
non-domestic organizations. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Ph.D./M.D./Other Professional Commercial Government Nonprofit Academic Institution
|
| Abstract: |
This FOA encourages investigator-initiated
applications to develop new, high-priority research tools or techniques
of high priority to the zebrafish community that will help exploit the
power of the zebrafish as a vertebrate model for biomedical and
behavioral research.
Applications proposing tools or
techniques that will enhance the ability to detect or characterize
genes, proteins, molecules, and pathways of interest in development and
aging, organ formation, neural processes, behavior, sensory processing,
physiological processes, and disease processes are welcome.
Objectives to be addressed in applications submitted in response to the FOA include, but are not limited to, the following: 1.
Development and/or application of novel methods of mutagenesis (e.g.,
insertional, site-specific, conditional knockout vectors or systems) 2. Development of techniques supporting more efficient targeting of induced local lesions in genomes (TILLING) 3.
Development of technologies for gene inactivation and for gene
expression manipulation including, but not limited to, morpholino
oligonucleotides, new types of antisense technology, techniques for
homologous recombination, techniques for gene trapping, and strategies
for directing gene misexpression, or other transgenic methodologies 4. Development of new genetic or genomic tools or technologies that are of high priority for the zebrafish community 5. Development of techniques or technologies for measuring or characterizing proteins or other important molecules in vivo
However, applications that propose novel phenotyping methods or genetic screens will not be accepted in response to this FOA.
Participating
organizations include National Institute of Diabetes, Digestive, and
Kidney Diseases (NIDDK), Eunice Kennedy Shriver National Institute of
Child Health and Human Development (NICHD), National Cancer Institute (NCI), National Eye Institute (NEI), National
Heart, Lung, and Blood Institute (NHLBI), National Human Genome
Research Institute (NHGRI), National Institute on Alcohol Abuse and
Alcoholism (NIAAA), National Institute on Deafness and Other
Communication Disorders (NIDCD), National Institute of Dental and
Craniofacial Research (NIDCR), National Institute on Drug Abuse (NIDA),
National Institute of Environmental Health Sciences (NIEHS), National
Institute of General Medical Sciences (NIGMS), National Institute of
Mental Health (NIMH), and National Institute of Neurological Disorders
and Stroke (NINDS). |
| Contact Name: |
Dr. Rebekah S. Rasooly |
| Contact Address: |
Division of Kidney, Urologic, and Hematologic Diseases NIDDK/NIH Two Democracy Plaza 6707 Democracy Blvd., MSC 5458 |
| Contact City: |
Bethesda |
| Contact State: |
Maryland |
| Contact Zip: |
20892-5458 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 594-6007 |
| Contact Fax: |
+1 (301) 480-3510 |
| Contact Email: |
rr185i@nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PAR-08-139.html |
| Date Last Revised: |
April 9, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113373 |
| Keywords: |
Animal Models
|
| Sponsor Reference No: |
PAR-08-139 |
| Funding Type: |
Research
|
| COS Unique Id: |
113390 |
| Title: |
In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R21) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
June 16, 2008 October 16, 2008 February 16, 2009
|
| Deadline Note: |
The opening date is May 16, 2008. This opportunity will expire on May 8, 2011. |
| Upper Amount: |
$275,000 |
| Amount Note: |
This FOA utilizes the NIH Exploratory/Developmental
Grant (R21) mechanism. The total project period for an application
submitted in response to this funding opportunity may not exceed two
years. Direct costs are limited to $275,000 over an R21 two-year
period, with no more than $200,000 in direct costs allowed in any
single year. The R21 is not renewable.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include institutions of higher
education; nonprofits, for-profits, and small businesses; state
governments; U.S. territories or possessions; regional organizations;
non-domestic organizations; and eligible agencies of the federal
government. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Ph.D./M.D./Other Professional Commercial Government Nonprofit Academic Institution
|
| Abstract: |
This FOA, issued by the National Cancer Institute
(NCI), the National Institute of Environmental Health Sciences (NIEHS),
and the Office of Dietary Supplements (ODS), is designed to promote
research that will enhance the understanding of the relationship
between exposures to bioactive food components and/or environmental
chemicals in utero, hormonal and growth factor response, gene
expression or epigenetic changes, and subsequent mammary cancer risk in
preclinical models.
Although much evidence suggests that
dietary components are linked to cancer prevention, the specific
nutrients, sites of action, and role of exposure in utero remain
elusive. Similarly, there are data suggesting a role for environmental
agents, such as mycotoxins, heterocyclic amines, and environmental
chemicals with endocrine activity in the etiology of mammary cancer,
but for which the doses, windows of susceptibility, and mechanisms are
unclear. This FOA encourages applications that apply new
high-throughput genomic, epigenomic, proteomic, and metabolomic
technologies to determine how dietary exposures in utero influence
adult breast cancer susceptibility. The resulting information will help
define effective maternal dietary intervention strategies for breast
cancer prevention in offspring.
Using the NIH
Exploratory/Developmental Grant (R21) funding mechanism, this FOA
focuses on early and conceptual stages of research projects. |
| Contact Name: |
Leslie Hickman, Grants Management Specialist |
| Contact Address: |
National Cancer Institute Fairview Center Building, Suite 300 1003 West 7th Street |
| Contact City: |
Frederick |
| Contact State: |
Maryland |
| Contact Zip: |
21701-4106 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 846-1013 |
| Contact Fax: |
+1 (301) 451-5391 |
| Contact Email: |
HickmanL@mail.nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PA-08-141.html |
| Date Last Revised: |
April 10, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113390 |
| Keywords: |
Breast Cancer
Cancer Prevention
Environmental Medicine
Pregnancy
|
| Sponsor Reference No: |
PA-08-141 |
| Funding Type: |
Research
|
| COS Unique Id: |
113394 |
| Title: |
In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
June 5, 2008 October 5, 2008 February 5, 2009
|
| Deadline Note: |
The opening date is May 5, 2008. This opportunity will expire on May 8, 2011. |
| Amount Note: |
This FOA will utilize the NIH research project R01
grant mechanism. The total project period for an application submitted
in response to this funding opportunity may not exceed five years.
Applicants for an R01 award are not limited in dollars but need to
reflect the actual needs of the proposed project.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include institutions of higher
education; nonprofits, for-profits, and small businesses; state
governments; U.S. territories or possessions; regional organizations;
non-domestic organizations; and eligible agencies of the federal
government. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Ph.D./M.D./Other Professional Commercial Government Nonprofit Academic Institution
|
| Abstract: |
This FOA, issued by the National Cancer Institute
(NCI), the National Institute of Environmental Health Sciences (NIEHS),
and the Office of Dietary Supplements (ODS), is designed to promote
research that will enhance the understanding of the relationship
between exposures to bioactive food components and/or environmental
chemicals in utero, hormonal and growth factor response, gene
expression or epigenetic changes, and subsequent mammary cancer risk in
preclinical models.
Although much evidence suggests that
dietary components are linked to cancer prevention, the specific
nutrients, sites of action, and role of exposure in utero remain
elusive. Similarly, there are data suggesting a role for environmental
agents, such as mycotoxins, heterocyclic amines, and environmental
chemicals with endocrine activity in the etiology of mammary cancer,
but for which the doses, windows of susceptibility, and mechanisms are
unclear. This FOA encourages applications that apply new
high-throughput genomic, epigenomic, proteomic, and metabolomic
technologies to determine how dietary exposures in utero influence
adult breast cancer susceptibility. The resulting information will help
define effective maternal dietary intervention strategies for breast
cancer prevention in offspring.
Using the NIH Research Project
Grant (R01) funding mechanism, this FOA focuses on discrete, specified,
circumscribed projects based upon strong preliminary data. |
| Contact Name: |
Leslie Hickman, Grants Management Specialist |
| Contact Address: |
National Cancer Institute Fairview Center Building, Suite 300 1003 West 7th Street |
| Contact City: |
Frederick |
| Contact State: |
Maryland |
| Contact Zip: |
21701-4106 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 846-1013 |
| Contact Fax: |
+1 (301) 451-5391 |
| Contact Email: |
HickmanL@mail.nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PA-08-140.html |
| Date Last Revised: |
April 10, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113394 |
| Keywords: |
Breast Cancer
Cancer Prevention
Environmental Medicine
Pregnancy
|
| Sponsor Reference No: |
PA-08-140 |
| Funding Type: |
Research
|
| COS Unique Id: |
113421 |
| Title: |
Mitochondria in Cancer Epidemiology, Detection, Diagnosis, and Prognosis (R01) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
June 5, 2008 October 5, 2008 February 5, 2009
|
| Deadline Note: |
The opening date is May 5, 2008. This opportunity will expire on May 8, 2011. |
| Amount Note: |
This FOA will utilize the NIH research project R01
grant mechanism. The total project period for an application submitted
in response to this funding opportunity may not exceed five years.
Applicants for an R01 award are not limited in dollars but need to
reflect the actual needs of the proposed project.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include public and
state-controlled institutions of higher education; private institutions
of higher education; nonprofits, for-profits, and small businesses;
state governments; U.S. territories or possessions; non-domestic
organizations; regional organizations; and eligible agencies of the
federal government. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Commercial Government Nonprofit Academic Institution
|
| Abstract: |
The purpose of this FOA is to stimulate the
development and validation of novel mitochondrial (mt) DNA biomarkers
for early detection, diagnosis, prognosis, and risk assessment of
cancer. This FOA will stimulate research on either mutations in mtDNA
and/or mitochondrial proteome analysis, for identification of
additional indicators of tumor development and progression.
Some of the specific questions that may be addressed in response to this FOA include, but are not limited to, the following: 1.
Are mitochondrial genomic and proteomic profiles useful for
identification of individuals who are at high-risk for cancer before
clinical manifestation of disease? 2. Is an increased ratio of
haplotypes within the mitochondrial genome associated with risk of
developing cancer? If so, can these parameters help explain racial and
ethnic differences in cancer risk? 3. Are there modifiable or host
factors that can influence the correlation between mtDNA mutations,
mitochondrial dysfunction, and cancer risk? 4. Are alterations in
the mitochondrial genome and proteome associated with intermediate
disease states in the neoplastic pathway, such as precursor lesions? 5.
Are mtDNA alterations (such as somatic mutations and structural
rearrangements including duplications and deletions) correlated with
development of various cancers? 6. Can mutations or instability in mtDNA prognosticate specific types of tumorigenesis or malignant transformation? 7.
How can mitochondrial markers be utilized to predict disease
progression and identify novel therapeutic targets? The mitochondrial
markers may comprise point mutations, deletions, amplifications, and
SNPs; alterations in mitochondrial morphology/clustering; and nuclear
proteins that affect mitochondrial function. 8. Can novel technology be developed for high-throughput analysis and imaging of mitochondrial clustering? 9. Are there unique mtDNA mutations associated with specific types of cancers? 10. Can mtDNA mutations be detected in pre-malignant lesions, such as prostate intraepithelial neoplasia (PIN)? 11.
Can high throughput diagnostic assays that are based upon mtDNA
mutations (or in combination with other markers), be developed for
noninvasive detection and or monitoring of cancer? 12. Can nutrition
or chemopreventive agents reduce mtDNA instability by regulating or
enhancing the efficiency of mtDNA repair mechanisms?
Using the
NIH Research Project Grant (R01) funding mechanism, this FOA focuses on
discrete, specified, circumscribed projects based upon strong
preliminary data. |
| Contact Name: |
Crystal Wolfrey |
| Contact Address: |
Office of Grants Administration National Cancer Institute 6120 Executive Boulevard EPS Suite 243, MSC 7150 |
| Contact City: |
Bethesda |
| Contact State: |
Maryland |
| Contact Zip: |
20892-7150 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 496-8634 |
| Contact Fax: |
+1 (301) 496-8601 |
| Contact Email: |
wolfreyc@mail.nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PA-08-143.html |
| Date Last Revised: |
April 11, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113421 |
| Keywords: |
Biomarkers
Cancer Genetics
Epidemiology
|
| Sponsor Reference No: |
PA-08-143 |
| Funding Type: |
Research
|
| COS Unique Id: |
113422 |
| Title: |
Mitochondria in Cancer Epidemiology, Detection, Diagnosis, and Prognosis (R21) |
| Sponsor: |
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
|
| Sponsor Type: |
Federal, U.S. |
| Deadline: |
June 16, 2008 October 16, 2008 February 16, 2009
|
| Deadline Note: |
The opening date is May 16, 2008. This opportunity will expire on May 8, 2011. |
| Upper Amount: |
$275,000 |
| Amount Note: |
This FOA utilizes the NIH Exploratory/Developmental
Grant (R21) mechanism. The total project period for an application
submitted in response to this funding opportunity may not exceed two
years. Direct costs are limited to $275,000 over an R21 two-year
period, with no more than $200,000 in direct costs allowed in any
single year. The R21 is not renewable.
This program does not require cost sharing. |
| Eligibility: |
Eligible applicants include public and
state-controlled institutions of higher education; private institutions
of higher education; nonprofits, for-profits, and small businesses;
state governments; U.S. territories or possessions; non-domestic
organizations; regional organizations; and eligible agencies of the
federal government. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Small Business Commercial Government Nonprofit Academic Institution
|
| Abstract: |
The purpose of this FOA is to stimulate the
development and validation of novel mitochondrial (mt) DNA biomarkers
for early detection, diagnosis, prognosis, and risk assessment of
cancer. This FOA will stimulate research on mutations in mtDNA for
identification of additional indicators of tumor development and
progression, including mitochondrial somatic mutations and
mitochondrial haplogroups.
Some of the specific questions that may be addressed in response to this FOA include, but are not limited to, the following: 1. Are mitochondrial markers useful for identification of individuals who are at high-risk for cancer before clinical onset? 2.
Are mitochondrial characteristics or haplotypes associated with risk of
developing cancer? If so, can these parameters help explain racial and
ethnic differences in cancer risk? 3. Are there modifiable or host factors that can influence the relationship between mtDNA characteristics and cancer risk? 4.
Are alterations in mitochondrial function correlated with intermediate
disease state in the neoplastic pathway, such as precursor lesions? 5. Are genetic and mtDNA alterations (such as somatic mutations, deletions) correlated with cancer development? 6. Can mutations or instability in mtDNA prognosticate tumorigenesis or malignant transformation? 7.
How can mitochondrial markers be utilized to predict disease
progression and identify novel therapeutic targets? The mitochondrial
markers may comprise point mutations, deletions, amplifications, and
SNPs; alterations in mitochondrial morphology/clustering; and nuclear
proteins that impact mitochondrial function 8. Can novel technology be developed for high-throughput analysis and imaging of mitochondrial clustering? 9. Are there unique mtDNA mutations associated with specific types of cancers? 10. Can mtDNA mutations be detected in pre-malignant lesions, such as prostate intraepithelial neoplasia (PIN)? 11.
Can high throughput diagnostic assays that are based upon mtDNA
mutations (or in combination with other markers) be developed for
noninvasive detection and or monitoring of cancer? 12. Can nutrition or chemopreventive agents reduce mtDNA instability by regulating repair mechanisms?
Using
the NIH Exploratory/Developmental Grant (R21) funding mechanism, this
FOA focuses on early and conceptual stages of research projects. |
| Contact Name: |
Crystal Wolfrey |
| Contact Address: |
Office of Grants Administration National Cancer Institute 6120 Executive Boulevard EPS Suite 243, MSC 7150 |
| Contact City: |
Bethesda |
| Contact State: |
Maryland |
| Contact Zip: |
20892-7150 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (301) 496-8634 |
| Contact Fax: |
+1 (301) 496-8601 |
| Contact Email: |
wolfreyc@mail.nih.gov |
| URL for more information: |
http://grants1.nih.gov/grants/guide/pa-files/PA-08-144.html |
| Date Last Revised: |
April 11, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=113422 |
| Keywords: |
Biomarkers
Cancer Genetics
Epidemiology
|
| Sponsor Reference No: |
PA-08-144 |
| Funding Type: |
Research
|
| COS Unique Id: |
184 |
| Title: |
Postdoctoral Research Fellowships |
| Sponsor: |
Whitney Foundation, Helen Hay
|
| Sponsor Type: |
Private Foundation |
| Deadline: |
July 15, 2008
|
| Amount: |
$43,000 |
| Amount Note: |
The fellowship is for a period of three years,
contingent on performance satisfactory to the foundation's Scientific
Advisory Committee. One- and two-year fellowships are not considered.
The
current stipend and expense allowance is $43,000 in the first year,
$44,000 in the second year, and $45,000 in the third year.
The
annual research allowance of $2,500 is given to the fellow's laboratory
to help defray research expenses, such as lab supplies, computers,
health insurance, etc. Its use is wholly at the discretion of the
fellow's supervisor, except that no part of it may be used for
institutional overhead.
There is a dependent child allowance of $1,000 per annum for each child. There is no allowance for a spouse. |
| Eligibility: |
Candidates who hold, or are in the final stages of
obtaining, the Ph.D., M.D., or equivalent degree and are seeking
beginning postdoctoral training in basic biomedical research are
eligible to apply for a fellowship. The foundation accepts applications
from candidates who have no more than one year of postdoctoral research
experience at the time of the deadline for submitting the application
(July 16) and who have received a Ph.D. (or D.Phil. or equivalent)
degree no more than two years before the deadline, or an M.D. degree no
more than three years before the deadline.
Fellowships may be
awarded to U.S. citizens planning to work in laboratories either in the
United States, Canada, or abroad and also to foreign nationals for
research in laboratories in the United States only. The foundation
expects that most applicants will be resident in North America at the
time of application. Foreign students will need to obtain appropriate
visa documentation, as required by U.S. Immigration.
Applications
from established scientists or advanced fellows will not be considered.
The fellowships are for early postdoctoral training only. Clinical
house-staff training does not count as "postdoctoral laboratory
training."
The foundation will not ordinarily consider
applicants who plan tenure of the fellowship in the laboratory in which
they have already received extensive predoctoral or postdoctoral
training. The aim of the fellowship is to broaden postdoctoral training
and experience, and a significant change of venue is advisable. Because
the number of available fellowships is limited, the foundation does not
make more than one award in any one year for training with a given
supervisor, and in addition, will not support more than two fellows per
laboratory at one time. Although the foundation accepts multiple
applications from the same laboratory in the same funding year, the
foundation urges supervisors to support only one application if
possible. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Ph.D./M.D./Other Professional
|
| Abstract: |
The Helen Hay Whitney Foundation supports early postdoctoral research training in all basic biomedical sciences.
To
attain its ultimate goal of increasing the number of imaginative,
well-trained and dedicated medical scientists, the foundation grants
financial support of sufficient duration to help further the careers of
young men and women engaged in biological or medical research.
The
foundation expects that fellowship training will be obtained in an
academic setting. The selection of a commercial or industrial
laboratory for the training experience is not acceptable. |
| Contact Address: |
Helen Hay Whitney Foundation 20 Squadron Boulevard, Suite 630 |
| Contact City: |
New York |
| Contact State: |
New York |
| Contact Zip: |
10956 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (845) 639-6799 |
| Contact Fax: |
+1 (845) 639-6798/+1 (646) 304-7133 |
| Contact Email: |
hhwf@earthlink.net |
| URL for more information: |
http://www.hhwf.org/HTMLSrc/ResearchFellowships.html |
| Date Last Revised: |
April 7, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=184 |
| Keywords: |
Biological Sciences
Biomedical Research (Multidisciplinary)
Biomedical Research Training
Health and Medicine
|
| Funding Type: |
Postdoctoral Award
|
| COS Unique Id: |
2793 |
| Title: |
Beckman Young Investigators (BYI) Program |
| Sponsor: |
Beckman Foundation, Arnold and Mabel
|
| Sponsor Type: |
Private Foundation |
| Deadline: |
October 1, 2008
|
| Deadline Note: |
All application materials, including reference letters, must be received before 5:00 P.M. PST on the deadline.
Internal
coordination required. No more than two candidates may apply from any
one institution. If the foundation receives more than two applications
from any one institution, only the first two received shall be
considered for review. Institutions that submit more than two
applications will be rejected in their entirety. |
| Upper Amount: |
$300,000 |
| Amount Note: |
Projects are normally funded for a period of three
years. Grants are normally in the range of $300,000 over the term of
the project. The foundation does not provide for overhead or for
indirect costs. |
| Eligibility: |
The BYI program is open to persons with
tenure-track appointments in academic and nonprofit institutions that
conduct fundamental research in the chemical and life sciences.
Candidates must be citizens or permanent residents of the United States
at the time of application. The candidate should not have completed
more than three full years in his or her tenure-track or other
comparable independent research appointment. Regardless of eligibility
under this rule, no individual may apply for a BYI award more than
three times. |
| Citizenship or Residency: |
United States
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Ph.D./M.D./Other Professional Nonprofit Academic Institution
|
| Abstract: |
The Arnold and Mabel Beckman Foundation makes
grants to nonprofit research institutions to promote research in
chemistry and the life sciences, broadly interpreted, and particularly
to foster the invention of methods, instruments, and materials that
will open up new avenues of research in science. The BYI Program is
intended to provide research support to the most promising young
faculty members in the early stages of academic careers in the chemical
and life sciences.
Additional Contact: Kathlene Williams, Executive Assistant Arnold and Mabel Beckman Foundation P.O. Box 13219 Newport Beach, California 92658 Phone +1 (949) 721-2222 Fax +1 (949) 721-2225 k.williams@beckman-foundation.com |
| Contact Name: |
Program Administrator |
| Contact Address: |
Arnold and Mabel Beckman Foundation P.O. Box 13219 |
| Contact City: |
Newport Beach |
| Contact State: |
California |
| Contact Zip: |
92658 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (949) 721-2222 |
| Contact Fax: |
+1 (949) 721-2225 |
| Contact Email: |
beckmanprograms@yahoo.com |
| URL for more information: |
http://www.beckman-foundation.com/byi_guides.html |
| Date Last Revised: |
April 8, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=2793 |
| Keywords: |
Chemical Sciences
Health and Medicine
Life Sciences
|
| Funding Type: |
Training, Scholarship, or Fellowship
Research
|
| COS Unique Id: |
61141 |
| Title: |
Target Identification in Lupus (TIL) Grant |
| Sponsor: |
Alliance for Lupus Research (ALR)
|
| Sponsor Type: |
Other Nonprofit |
| Deadline: |
July 15, 2008
|
| Deadline Note: |
The deadline is for submission of the full applications.
The
ALR requests that investigators submit a letter of intent (LOI) online
no later than 5:00 P.M. (EST) on April 30, 2008. Submission of the LOI
does not commit the investigator to submitting an application, and is
not required for submitting a full application. |
| Upper Amount: |
$500,000 |
| Amount Note: |
Each grant of up to $500,000 will be awarded for a
two-year time frame. Grants will be activated on February 2, 2009.
Funding for the initial two-year period will be made for up to $250,000
per year including indirect costs. A grant renewal application and a
second round of peer review will be required before the two-year point
for continued funding of the final two years of the project. If
awarded, the second phase of a project may be funded for a maximum of
two additional years for an amount determined during the peer review
process. Indirect costs are not to exceed 8 percent of the total amount
approved. |
| Eligibility: |
Individuals with doctoral degrees (M.D., Ph.D.,
D.O., or equivalent) are eligible to apply. Scientific independence, as
evidenced by direction of a research program or a publication record or
other experience that establishes scientific leadership, is necessary
to apply. The ALR does not impose geographic restrictions on its
applicants and investigators working anywhere in the world are eligible
and encouraged to apply. The ALR is willing to appropriately support
research in industry or collaborations between academia and industry. |
| Citizenship or Residency: |
Unrestricted
|
| Activity Location: |
Unrestricted
|
| Requirements: |
Ph.D./M.D./Other Professional
|
| Abstract: |
The ALR funds research that will accelerate the
development of new treatments of lupus. As such, grant proposals should
be innovative in direction and utilize state-of-the-art techniques.
Fundamental studies in genetics, immunology, cell biology, and
molecular biology to identify and characterize molecular systems must
be oriented towards the development of drugs that would prevent and/or
ameliorate clinical signs and symptoms of lupus.
Additional Contact: Diomaris Gonzalez, Manager of Research Administration Phone +1 (212) 218-2840 or +1 (800) 867-1743 dgonzalez@lupusresearch.org |
| Contact Address: |
Alliance for Lupus Research 28 West 44th Street, Suite 501 |
| Contact City: |
New York |
| Contact State: |
New York |
| Contact Zip: |
10036 |
| Contact Country: |
United States |
| Contact Phone: |
+1 (212) 218-2840 |
| Contact Fax: |
+1 (212) 218-2848 |
| Contact Email: |
grant.administration@lupusresearch.org |
| URL for more information: |
http://lupusresearch.org/research/TIL.html |
| Date Last Revised: |
April 9, 2008 |
| URL from COS to Bookmark this record: |
http://fundingopps.cos.com/cgi-bin/getRec?id=61141 |
| Keywords: |
Autoimmunity
Lupus
|
| Funding Type: |
Research
|
|
|
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