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Concept Analysis of Psychosocial Distress Among African American and Latine Men Who Have Sex With Men: Implications for HIV Care

The aim of this study is to provide conceptual clarity on psychosocial distress among African American and Latine men who have sex with men living with human immunodeficiency virus. As experienced by African American and Latine men who have sex with men living with human immunodeficiency virus, psychosocial distress is defined as a state of suffering due to uncontrollable structural and/or social factors that threaten the individual's existence and/or livelihood based on their social identity as a racial/ethnic, sexual minority.

Ecological change increases malaria risk in the Brazilian Amazon

Deforestation in the Amazon is thought to increase malaria. However, some studies have found the opposite or no effect. Limitations of these studies include the use of annual data (ignoring transmission seasonality), coarse spatial scale, limited time series, and often neglect frontier malaria dynamics.

Potential for an Electronic Clinical Decision Support Tool to Support Appropriate Antibiotic Use for Pediatric Diarrhea Among Village Doctors in Bangladesh

Diarrhea is a significant cause of morbidity among children in low- and middle-income countries (LMICs), and is responsible for over 500 000 deaths per year. In many LMICs, informally trained healthcare providers are the first point of care for children with diarrhea. In Bangladesh, “village doctors” practice allopathic medicine with limited formal training and provide healthcare services to approximately two-thirds of Bangladesh’s population.

Hepatitis B virus (HBV) viremia despite tenofovir disoproxil fumarate-containing antiretroviral therapy in persons with HBV/HIV coinfection

HIV/HBV coinfection is common in areas that are endemic for both viruses. In 2015, ∼2.7 million (7.4 %) of 36.7 million people living with HIV worldwide were infected with HBV, with 71 % (1.96 million) living in sub-Saharan Africa. Complications of chronic HBV infection like cirrhosis, hepatocellular carcinoma, and death are associated with HBV replication

Interleukin-22 Promotes Cell Proliferation to Combat Virus Infection in Human Intestinal Epithelial Cells

Interferon lambdas (IFN-λs) are crucial to control virus infections at mucosal surfaces. Interleukin-22 (IL-22) was reported to help IFN-λ control rotavirus infection in the intestinal epithelium of mice either by aiding in the induction of interferon-stimulated genes (ISGs) or by increasing cell proliferation thereby clearing virally infected cells. We investigated whether IL-22 and IFN-λs exhibit similar synergistic effects in human intestinal epithelial cells (IECs) models.