Joseph Larkin,
Associate Professor
Department:
AG-MICROBIOLOGY / CELL SCI
Business Phone:
(352) 392-6884
Business Email:
jlarkin3@ufl.edu
Teaching Profile
Courses Taught
2016-2025
MCB7979 Advanced Research
2016-2018,2020-2025
MCB7980 Research for Doctoral Dissertation
2020-2021
MCB6971 Research for Master’s Thesis
2008-2025
MCB7922 Journal Colloquy
2010-2025
MCB6355 Microbial/Host Defense
2018-2025
MCB4934 Special Topics in Microbiology and Cell Science
2011-2025
PCB4233 Immunology
2019-2020
MCB4911 Supervised Research in Microbiology and Cell Science
2019-2020,2022-2025
MCB4915 Honors Thesis Research in Microbiology and Cell Science
2008-2025
PCB5235 Immunology
2018
GMS7980 Research for Doctoral Dissertation
2018
FOS6971 Research for Master’s Thesis
2023-2024
MCB6940 Supervised Teaching
Publications
Academic Articles
2025
Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America.
122(1)
[DOI] 10.1073/pnas.2422321121.
[PMID] 39793074.
2024
A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1513157.
[PMID] 39867889.
2024
COVID-19 booster enhances IgG mediated viral neutralization by human milk in vitro.
Frontiers in nutrition.
11
[DOI] 10.3389/fnut.2024.1289413.
[PMID] 38406184.
2023
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination
Journal of Perinatology.
43(6):775-781
[DOI] 10.1038/s41372-022-01581-5.
2023
Editorial response to Cosentino and Marino RE:Â detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination
Journal of Perinatology.
43(6):828-829
[DOI] 10.1038/s41372-023-01660-1.
[PMID] 37024528.
2023
SOCS1-KIR Peptide in PEGDA Hydrogels Reduces Pro-Inflammatory Macrophage Activation.
Macromolecular bioscience.
23(9)
[DOI] 10.1002/mabi.202300237.
[PMID] 37337867.
2022
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination.
Research square.
[DOI] 10.21203/rs.3.rs-1950944/v1.
[PMID] 36032985.
2022
Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-11338-x.
[PMID] 35505065.
2021
Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo
PLOS Pathogens.
17(5)
[DOI] 10.1371/journal.ppat.1009465.
[PMID] 33956909.
2021
Detection of SARS-CoV-2-Specific IgA in the Human Milk of COVID-19 Vaccinated Lactating Health Care Workers.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
16(12):1004-1009
[DOI] 10.1089/bfm.2021.0122.
[PMID] 34427487.
2021
Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-86017-4.
[PMID] 33737712.
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.00611.
[PMID] 32351504.
2019
Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer.
Frontiers in pharmacology.
10
[DOI] 10.3389/fphar.2019.00324.
[PMID] 31105556.
2017
Editorial: The Dynamic Role of Suppressor of Cytokine Signaling Proteins in the Regulation of Immune and Autoimmune Responses.
Frontiers in immunology.
8
[DOI] 10.3389/fimmu.2017.00825.
[PMID] 28769931.
2016
SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis).
Mediators of inflammation.
2016
[PMID] 27703302.
2016
Sparse serological evidence of Plasmodium vivax transmission in the Ouest and Sud-Est departments of Haiti.
Acta tropica.
162:27-34
[DOI] 10.1016/j.actatropica.2016.05.011.
[PMID] 27230796.
2016
Therapeutic Potential for Targeting the Suppressor of Cytokine Signalling-1 Pathway for the Treatment of SLE.
Scandinavian journal of immunology.
84(5):299-309
[DOI] 10.1111/sji.12475.
[PMID] 27781323.
2015
A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00574.
[PMID] 26617608.
2015
SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00183.
[PMID] 25954276.
2015
Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.
Journal of autoimmunity.
62:31-8
[DOI] 10.1016/j.jaut.2015.05.011.
[PMID] 26094775.
2014
Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti.
Malaria journal.
13
[DOI] 10.1186/1475-2875-13-361.
[PMID] 25218803.
2013
Isolation and th17 differentiation of naïve CD4 T lymphocytes.
Journal of visualized experiments : JoVE.
(79)
[DOI] 10.3791/50765.
[PMID] 24121559.
2013
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells.
Frontiers in immunology.
4
[DOI] 10.3389/fimmu.2013.00469.
[PMID] 24391643.
2013
Th17 Cells in Immunity and Autoimmunity
Clinical and Developmental Immunology.
2013:1-16
[DOI] 10.1155/2013/986789.
[PMID] 24454481.
2012
Comparison of Three Chain-of-States Methods: Nudged Elastic Band and Replica Path with Restraints or Constraints.
Journal of chemical theory and computation.
8(12):5035-5051
[PMID] 23526888.
2011
Efficient Calculation of QM/MM Frequencies with the Mobile Block Hessian.
Journal of chemical theory and computation.
7(2):496-514
[DOI] 10.1021/ct100473f.
[PMID] 26596169.
2011
Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950).
187(5):2666-76
[DOI] 10.4049/jimmunol.1003819.
[PMID] 21788442.
2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950).
186(6):3538-46
[DOI] 10.4049/jimmunol.1001864.
[PMID] 21317395.
2011
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
Journal of neuroimmunology.
232(1-2):108-18
[DOI] 10.1016/j.jneuroim.2010.10.018.
[PMID] 21131060.
2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one.
5(5)
[DOI] 10.1371/journal.pone.0010507.
[PMID] 20463897.
2008
CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950).
180(2):833-41
[PMID] 18178822.
2007
Spontaneous autoreactive memory B cell formation driven by a high frequency of autoreactive CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950).
178(8):4793-802
[PMID] 17404260.
2006
Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection.
Immunological reviews.
212:74-85
[PMID] 16903907.
2005
Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.
Journal of immunology (Baltimore, Md. : 1950).
174(12):7684-91
[PMID] 15944269.
2004
CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen.
Journal of immunology (Baltimore, Md. : 1950).
173(1):236-44
[PMID] 15210780.
2003
Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950).
171(11):5678-82
[PMID] 14634074.
2001
Differential properties of two putative nuclear localization sequences found in the carboxyl-terminus of human ifn-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
21(6):341-8
[PMID] 11440631.
2001
Nuclear translocation of IFN-gamma is an intrinsic requirement for its biologic activity and can be driven by a heterologous nuclear localization sequence.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
21(11):951-9
[PMID] 11747627.
2000
Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
20(6):565-76
[PMID] 10888113.
2000
The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site.
Journal of cell science.
113 ( Pt 15):2771-81
[PMID] 10893192.
1998
Cytokine-receptor complexes as chaperones for nuclear translocation of signal transducers.
Biochemical and biophysical research communications.
244(3):607-14
[PMID] 9535713.
1998
Human IFN gamma receptor cytoplasmic domain: expression and interaction with HuIFN gamma.
Biochemical and biophysical research communications.
243(1):170-6
[PMID] 9473500.
1998
Hypothesis: ligand/receptor-assisted nuclear translocation of STATs.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
218(3):149-55
[PMID] 9648932.
Grants
Jun 2023
ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2022
– Jan 2024
Human milk antibody response to COVID-19 vaccination and protection to breastfeeding infants
Role: Principal Investigator
Funding: GERBER FOUNDATION
Jan 2022
– Dec 2023
SBT-100 Regulation of Cytokine Signaling and Autoimmunity
Role: Principal Investigator
Funding: *SINGH BIOTECHNOLOGY
Apr 2021
– Dec 2023
Mitigation of Equine Recurrent Uveitis through topical suppressor of Cytokine Signaling-1 mimetic peptide
Role: Principal Investigator
Funding: GRAYSON JOCKEY CLUB RES FOU
Jun 2019
– Oct 2022
Function and protein cargo of exosomes in antigen presenting cells during Salmonella infection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2019
– Apr 2020
SBIR: Biomaterial-Based Delivery of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type 1 Diabetes
Role: Principal Investigator
Funding: ONEVAX
via NATL INST OF HLTH NIDDK
Sep 2018
– Aug 2021
OR-DRPD-ROF2018: Identification of the first extracellular nicotinamide adenine dinucleotide-binding receptor in animal cells
Role: Co-Investigator
Funding: UF RESEARCH
May 2018
– Aug 2018
2018 National Psoriasis Foundation Summer Student Research Grant
Role: Principal Investigator
Funding: National Psoriasis Foundation
Sep 2017
– Jan 2025
Mitigation of Equine Recurrent Uveitis through Topical Application of Suppressor of Cytokine Signaling Mimetic Peptide-Pilot
Role: Principal Investigator
Funding: HHMD LLC
Sep 2017
– Aug 2024
Florida Pathways to Success: a research university/minority-serving community college partnership to enhance retention and diversity of transfer students
Role: Project Manager
Funding: NATL SCIENCE FOU
Aug 2017
– May 2018
Therapeutic Administration of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type 1 Diabetes
Role: Principal Investigator
Funding: ONEVAX
via NATL INST OF HLTH NIAID
Jan 2017
– Dec 2021
Broadening the STEM Pipeline with Research Experiences in Agricultural Science
Role: Project Manager
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2016
– Aug 2017
AAI CAREERS IN IMMUNOLOGY FELLOWSHIP
Role: Principal Investigator
Funding: AM ASSN OF IMMUNOLOGISTS
Aug 2016
– Dec 2017
Inhibition of Psoriasis through Suppressor of Cytokine Signaling-1 Regulation
Role: Principal Investigator
Funding: National Psoriasis Foundation
Mar 2015
– Dec 2016
Modulation of T lymphocyte plasticity and autoimmune effector functions through suppressor of cytokine signaling regulation (SOCS)
Role: Principal Investigator
Funding: BENAROYA RES INST AT VA MASON
via NATL INST OF HLTH NIAID
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Contact Details
Phones:
- Business:
- (352) 392-6884
Emails:
- Business:
- jlarkin3@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 110700
GAINESVILLE FL 32611 - Business Street:
-
1355 MUSEUM DR
GAINESVILLE FL 32611