Joseph Larkin

Joseph Larkin,

Associate Professor

Department: AG-MICROBIOLOGY / CELL SCI
Business Phone: (352) 392-6884
Business Email: jlarkin3@ufl.edu

Teaching Profile

Courses Taught
2016-2025
MCB7979 Advanced Research
2016-2018,2020-2025
MCB7980 Research for Doctoral Dissertation
2020-2021
MCB6971 Research for Master’s Thesis
2008-2025
MCB7922 Journal Colloquy
2010-2025
MCB6355 Microbial/Host Defense
2018-2025
MCB4934 Special Topics in Microbiology and Cell Science
2011-2025
PCB4233 Immunology
2019-2020
MCB4911 Supervised Research in Microbiology and Cell Science
2019-2020,2022-2024
MCB4915 Honors Thesis Research in Microbiology and Cell Science
2008-2025
PCB5235 Immunology
2018
GMS7980 Research for Doctoral Dissertation
2018
FOS6971 Research for Master’s Thesis
2023-2024
MCB6940 Supervised Teaching

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-2066-6814

Publications

2024
COVID-19 booster enhances IgG mediated viral neutralization by human milk in vitro.
Frontiers in nutrition. 11 [DOI] 10.3389/fnut.2024.1289413. [PMID] 38406184.
2023
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination
Journal of Perinatology. 43(6):775-781 [DOI] 10.1038/s41372-022-01581-5.
2023
Editorial response to Cosentino and Marino RE: detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination
Journal of Perinatology. 43(6):828-829 [DOI] 10.1038/s41372-023-01660-1. [PMID] 37024528.
2023
SOCS1-KIR Peptide in PEGDA Hydrogels Reduces Pro-Inflammatory Macrophage Activation.
Macromolecular bioscience. 23(9) [DOI] 10.1002/mabi.202300237. [PMID] 37337867.
2022
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination.
Research square. [DOI] 10.21203/rs.3.rs-1950944/v1. [PMID] 36032985.
2022
Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-11338-x. [PMID] 35505065.
2021
Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo
PLOS Pathogens. 17(5) [DOI] 10.1371/journal.ppat.1009465. [PMID] 33956909.
2021
Detection of SARS-CoV-2-Specific IgA in the Human Milk of COVID-19 Vaccinated Lactating Health Care Workers.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 16(12):1004-1009 [DOI] 10.1089/bfm.2021.0122. [PMID] 34427487.
2021
Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-86017-4. [PMID] 33737712.
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.00611. [PMID] 32351504.
2019
Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer.
Frontiers in pharmacology. 10 [DOI] 10.3389/fphar.2019.00324. [PMID] 31105556.
2017
Editorial: The Dynamic Role of Suppressor of Cytokine Signaling Proteins in the Regulation of Immune and Autoimmune Responses.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00825. [PMID] 28769931.
2016
SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis).
Mediators of inflammation. 2016 [PMID] 27703302.
2016
Sparse serological evidence of Plasmodium vivax transmission in the Ouest and Sud-Est departments of Haiti.
Acta tropica. 162:27-34 [DOI] 10.1016/j.actatropica.2016.05.011. [PMID] 27230796.
2016
Therapeutic Potential for Targeting the Suppressor of Cytokine Signalling-1 Pathway for the Treatment of SLE.
Scandinavian journal of immunology. 84(5):299-309 [DOI] 10.1111/sji.12475. [PMID] 27781323.
2015
A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00574. [PMID] 26617608.
2015
SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00183. [PMID] 25954276.
2015
Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.
Journal of autoimmunity. 62:31-8 [DOI] 10.1016/j.jaut.2015.05.011. [PMID] 26094775.
2014
Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti.
Malaria journal. 13 [DOI] 10.1186/1475-2875-13-361. [PMID] 25218803.
2013
Isolation and th17 differentiation of naïve CD4 T lymphocytes.
Journal of visualized experiments : JoVE. (79) [DOI] 10.3791/50765. [PMID] 24121559.
2013
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00469. [PMID] 24391643.
2013
Th17 Cells in Immunity and Autoimmunity
Clinical and Developmental Immunology. 2013:1-16 [DOI] 10.1155/2013/986789. [PMID] 24454481.
2012
Comparison of Three Chain-of-States Methods: Nudged Elastic Band and Replica Path with Restraints or Constraints.
Journal of chemical theory and computation. 8(12):5035-5051 [PMID] 23526888.
2011
Efficient Calculation of QM/MM Frequencies with the Mobile Block Hessian.
Journal of chemical theory and computation. 7(2):496-514 [DOI] 10.1021/ct100473f. [PMID] 26596169.
2011
Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950). 187(5):2666-76 [DOI] 10.4049/jimmunol.1003819. [PMID] 21788442.
2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950). 186(6):3538-46 [DOI] 10.4049/jimmunol.1001864. [PMID] 21317395.
2011
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
Journal of neuroimmunology. 232(1-2):108-18 [DOI] 10.1016/j.jneuroim.2010.10.018. [PMID] 21131060.
2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one. 5(5) [DOI] 10.1371/journal.pone.0010507. [PMID] 20463897.
2008
CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950). 180(2):833-41 [PMID] 18178822.
2007
Spontaneous autoreactive memory B cell formation driven by a high frequency of autoreactive CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950). 178(8):4793-802 [PMID] 17404260.
2006
Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection.
Immunological reviews. 212:74-85 [PMID] 16903907.
2005
Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.
Journal of immunology (Baltimore, Md. : 1950). 174(12):7684-91 [PMID] 15944269.
2004
CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen.
Journal of immunology (Baltimore, Md. : 1950). 173(1):236-44 [PMID] 15210780.
2003
Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950). 171(11):5678-82 [PMID] 14634074.
2001
Differential properties of two putative nuclear localization sequences found in the carboxyl-terminus of human ifn-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(6):341-8 [PMID] 11440631.
2001
Nuclear translocation of IFN-gamma is an intrinsic requirement for its biologic activity and can be driven by a heterologous nuclear localization sequence.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(11):951-9 [PMID] 11747627.
2000
Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 20(6):565-76 [PMID] 10888113.
2000
The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site.
Journal of cell science. 113 ( Pt 15):2771-81 [PMID] 10893192.
1998
Cytokine-receptor complexes as chaperones for nuclear translocation of signal transducers.
Biochemical and biophysical research communications. 244(3):607-14 [PMID] 9535713.
1998
Human IFN gamma receptor cytoplasmic domain: expression and interaction with HuIFN gamma.
Biochemical and biophysical research communications. 243(1):170-6 [PMID] 9473500.
1998
Hypothesis: ligand/receptor-assisted nuclear translocation of STATs.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 218(3):149-55 [PMID] 9648932.

Grants

Jun 2023 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2022 – Jan 2024
Human milk antibody response to COVID-19 vaccination and protection to breastfeeding infants
Role: Principal Investigator
Funding: GERBER FOUNDATION
Jan 2022 – Dec 2023
SBT-100 Regulation of Cytokine Signaling and Autoimmunity
Role: Principal Investigator
Funding: *SINGH BIOTECHNOLOGY
Apr 2021 – Dec 2023
Mitigation of Equine Recurrent Uveitis through topical suppressor of Cytokine Signaling-1 mimetic peptide
Role: Principal Investigator
Funding: GRAYSON JOCKEY CLUB RES FOU
Jun 2019 – Oct 2022
Function and protein cargo of exosomes in antigen presenting cells during Salmonella infection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2019 – Apr 2020
SBIR: Biomaterial-Based Delivery of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type 1 Diabetes
Role: Principal Investigator
Funding: ONEVAX via NATL INST OF HLTH NIDDK
Sep 2018 – Aug 2021
OR-DRPD-ROF2018: Identification of the first extracellular nicotinamide adenine dinucleotide-binding receptor in animal cells
Role: Co-Investigator
Funding: UF RESEARCH
May 2018 – Aug 2018
2018 National Psoriasis Foundation Summer Student Research Grant
Role: Principal Investigator
Funding: National Psoriasis Foundation
Sep 2017 ACTIVE
Mitigation of Equine Recurrent Uveitis through Topical Application of Suppressor of Cytokine Signaling Mimetic Peptide-Pilot
Role: Principal Investigator
Funding: HHMD LLC
Sep 2017 ACTIVE
Florida Pathways to Success: a research university/minority-serving community college partnership to enhance retention and diversity of transfer students
Role: Project Manager
Funding: NATL SCIENCE FOU
Aug 2017 – May 2018
Therapeutic Administration of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type 1 Diabetes
Role: Principal Investigator
Funding: ONEVAX via NATL INST OF HLTH NIAID
Jan 2017 – Dec 2021
Broadening the STEM Pipeline with Research Experiences in Agricultural Science
Role: Project Manager
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2016 – Aug 2017
AAI CAREERS IN IMMUNOLOGY FELLOWSHIP
Role: Principal Investigator
Funding: AM ASSN OF IMMUNOLOGISTS
Aug 2016 – Dec 2017
Inhibition of Psoriasis through Suppressor of Cytokine Signaling-1 Regulation
Role: Principal Investigator
Funding: National Psoriasis Foundation
Mar 2015 – Dec 2016
Modulation of T lymphocyte plasticity and autoimmune effector functions through suppressor of cytokine signaling regulation (SOCS)
Role: Principal Investigator
Funding: BENAROYA RES INST AT VA MASON via NATL INST OF HLTH NIAID
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Contact Details

Phones:
Business:
(352) 392-6884
Emails:
Business:
jlarkin3@ufl.edu
Addresses:
Business Mailing:
PO Box 110700
GAINESVILLE FL 32611
Business Street:
1355 MUSEUM DR
GAINESVILLE FL 32611