Alberto Perez Antonanzas
ASO PROF
On This Page
About Alberto Perez Antonanzas
My laboratory is interested in the structures, dynamics and functionality of proteins, peptides, and nucleic acids and how their interactions lead to functionality. Our interest in recent years has been the study of molecular recognition principles in protein-peptide and protein-nucleic acids systems — to understand their role in disease, and technological applications to other areas such as sensors, or biomaterials. We develop and apply computational tools to predict structures, relative binding affinities and mechanisms of action. We co-develop and maintain the MELD (Modeling Employing Limited Data) to integrate sparse, ambiguous, and noisy data (e.g. from experiments) into simulations — thus our research is highly collaborative. At the University of Florida my group has established collaborations to incorporate new sources of experimental data such as CryoEM and NMR Chemical Shift perturbation towards structure determination. We combine these methods with more traditional approaches to map the energy landscape of the biomolecules to understand binding or folding landscapes.
Teaching Profile
Courses Taught
-
CHM6586 – Computational Chemistry
College of Liberal Arts and Sciences
-
CHM3400 – Physical Chemistry for the Biosciences
College of Liberal Arts and Sciences
-
CHM6590 – Physical Chemistry Seminar
College of Liberal Arts and Sciences
-
CHM4910 – Undergraduate Research
College of Liberal Arts and Sciences
-
CHM6470 – Chemical Bonding and Spectra I
College of Liberal Arts and Sciences
-
CHM6580 – Special Topics in Physical Chemistry
College of Liberal Arts and Sciences
-
CHM2050 – Honors General Chemistry 1 for Majors
College of Liberal Arts and Sciences
-
CHM6461 – Statistical Thermodynamics
College of Liberal Arts and Sciences
-
CHM4930 – Special Topics
College of Liberal Arts and Sciences
Publications
Academic Articles
Grants
-
Quantum Theory and Machine Learning for Molecules and Materials Thematic Program for 64th Sanibel Symposium
- Role:
- Co-Project Director/Principal Investigator
- Funding:
- US DEPT OF ENERGY
-
Advances in Coupled Cluster Theory
Active
- Role:
- Principal Investigator
- Funding:
- NATL SCIENCE FOU
-
Targeting the ET domain of BET proteins: specificity and selectivity
Active
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIGMS
-
CAREER: Enhanced Sampling Methods to Characterize Nucleic AcidStructure, Recognition Mechanisms and Function
Active
- Role:
- Principal Investigator
- Funding:
- NATL SCIENCE FOU
-
Towards rational computational design of self-assembling peptides
- Role:
- Principal Investigator
- Funding:
- US ARMY RESEARCH OFFICE
-
American Cancer Society Institutional Research Grant
Active
- Role:
- Project Manager
- Funding:
- AMERICAN CANCER SOCIETY
-
Quantum Chemistry of Radicals and Reactive Intermediates
- Role:
- Principal Investigator
- Funding:
- US DEPT OF ENERGY CHICAGO
Contact Details
- Business:
- (617) 680-4935
- Business:
- perez@chem.ufl.edu
- Business Mailing:
-
PO Box 117200
GAINESVILLE FL 32611