Daniel R Swale

Daniel R Swale,

Associate Professor; EPI Associate Director For Training And Special Projects

Department: AG-ENTOMOLOGY AND NEMATOLOGY
Business Phone: (352) 273-9149
Business Email: dswale@ufl.edu

About Daniel R Swale

Dr. Daniel Swale is an Associate Professor in the Emerging Pathogens Institute and Department of Entomology and Nematology at the University of Florida. Dr. Swale received his B.S. in Biology and Chemistry from Christopher Newport University (2008), his M.S. in Life Sciences from Virginia Tech (2009), and his Ph.D. in insect neurotoxicology from the University of Florida (2012). He then completed a postdoctoral fellowship in the Department of Anesthesiology at Vanderbilt Medical School focusing on the development of pharmacology for potassium ion channels involved in various human diseases. At EPI, his current research lies at the interface of physiology, toxicology, and molecular genetics to provide knowledge on the modes of action, discovery and development, and resistance of various drug and insecticide chemistries. Our lab studies the fundamental and applied aspects of physiology and toxicology by integrating toxicological, pharmacological, electrophysiological, and genomic approaches to address broad ranging hypotheses in model insects, arthropod vectors of human diseases, and agriculture pests. Specifically, the Swale Lab studies the physiotoxicology of ion channels and ion transporters that are understudied as a means to bridge the fundamental knowledge gap that limits our understanding of insect systems. In addition to fundamental physiotoxicology, a branch of the Swale Research Lab focuses on pathogen-vector interactions that alter physiological pathways to enhance pathogenesis of pathogens, alter arthropod behavior, or alter vector competency.

In his spare time, he enjoys fishing, hunting, and triathlons.

Teaching Profile

Courses Taught
2024-2025
PHC6722 Environmental and Global Health Research Methods Rotation

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-1055-8326

Publications

2024
Cross resistance to brevetoxin-3 by kdr and super-kdr mutations in house flies.
Pesticide biochemistry and physiology. 201 [DOI] 10.1016/j.pestbp.2024.105898. [PMID] 38685256.
2024
Repellent activity of essential oils to the Lone Star tick, Amblyomma americanum.
Parasites & vectors. 17(1) [DOI] 10.1186/s13071-024-06246-0. [PMID] 38711138.
2023
ATP-sensitive inward rectifier potassium channels regulate secretion of pro-feeding salivary proteins in the lone star tick (Amblyomma americanum).
International journal of biological macromolecules. 253(Pt 1) [DOI] 10.1016/j.ijbiomac.2023.126545. [PMID] 37652342.
2023
Bioinsecticidal activity of cajeput oil to pyrethroid-susceptible and -resistant mosquitoes.
Pesticide biochemistry and physiology. 193 [DOI] 10.1016/j.pestbp.2023.105458. [PMID] 37248001.
2023
Catalyzing systemic movement of inward rectifier potassium channel inhibitors for antifeedant activity against the cotton aphid, Aphis gossypii (Glover)
Pest Management Science. 79(1):194-205 [DOI] 10.1002/ps.7188.
2023
Defining the toxicological profile of 4-hydroxyphenylpyruvate dioxygenase-directed herbicides to Aedes aegypti and Amblyomma americanum.
Pesticide biochemistry and physiology. 194 [DOI] 10.1016/j.pestbp.2023.105532. [PMID] 37532340.
2023
Functional interactions between potassium-chloride cotransporter (KCC) and inward rectifier potassium (Kir) channels in the insect central nervous system.
Pesticide biochemistry and physiology. 192 [DOI] 10.1016/j.pestbp.2023.105389. [PMID] 37105628.
2023
Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi.
Frontiers in cellular and infection microbiology. 13 [DOI] 10.3389/fcimb.2023.1253670. [PMID] 37965264.
2023
Molecular targets of insecticides and herbicides – Are there useful overlaps?
Pesticide biochemistry and physiology. 191 [DOI] 10.1016/j.pestbp.2023.105340. [PMID] 36963955.
2023
Potassium ion channels as a molecular target to reduce virus infection and mortality of honey bee colonies.
Virology journal. 20(1) [DOI] 10.1186/s12985-023-02104-0. [PMID] 37349817.
2022
Acute toxicity of atrazine, alachlor, and chlorpyrifos mixtures to honey bees.
Pesticide biochemistry and physiology. 188 [DOI] 10.1016/j.pestbp.2022.105271. [PMID] 36464376.
2022
ATP-sensitive inward rectifier potassium channels reveal functional linkage between salivary gland function and blood feeding in the mosquito, Aedes aegypti
Communications Biology. 5(1) [DOI] 10.1038/s42003-022-03222-1. [PMID] 35347209.
2021
Characterization of Toxicological and Neurophysiological Effects of Natural Product Based Chromenes to Fall Armyworm, Spodoptera frugiperda
Journal of Economic Entomology. 114(6):2485-2492 [DOI] 10.1093/jee/toab172.
2020
Comparative effects of technical‐grade and formulated chlorantraniliprole to the survivorship and locomotor activity of the honey bee, Apis mellifera (L.)
Pest Management Science. 76(8):2582-2588 [DOI] 10.1002/ps.5832.
2019
Chemical inhibition of Kir channels reduces salivary secretions and phloem feeding of the cotton aphid, Aphis gossypii (Glover)
Pest Management Science. 75(10):2725-2734 [DOI] 10.1002/ps.5382.
2019
Functional Coupling of K+–Cl Cotransporter (KCC) to GABA-Gated Cl Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities
ACS Chemical Neuroscience. 10(6):2765-2776 [DOI] 10.1021/acschemneuro.8b00697.
2019
Inward rectifier potassium (Kir) channels mediate salivary gland function and blood feeding in the lone star tick, Amblyomma americanum
PLOS Neglected Tropical Diseases. 13(2) [DOI] 10.1371/journal.pntd.0007153. [PMID] 30730880.
2019
Is DEET a dangerous neurotoxicant?
Pest Management Science. 75(8):2068-2070 [DOI] 10.1002/ps.5476.
2018
Development of an autodissemination strategy for the deployment of novel control agents targeting the common malaria mosquito, Anopheles quadrimaculatus say (Diptera: Culicidae)
PLOS Neglected Tropical Diseases. 12(4) [DOI] 10.1371/journal.pntd.0006259. [PMID] 29641515.
2017
Role of inward rectifier potassium channels in salivary gland function and sugar feeding of the fruit fly, Drosophila melanogaster
Pesticide Biochemistry and Physiology. 141:41-49 [DOI] 10.1016/j.pestbp.2016.11.005.
2016
ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.
ACS chemical neuroscience. 7(7):1013-23 [DOI] 10.1021/acschemneuro.6b00111. [PMID] 27184474.
2015
Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae.
Pesticide biochemistry and physiology. 121:116-21 [DOI] 10.1016/j.pestbp.2015.03.001. [PMID] 26047119.
2015
Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management.
Pest management science. 71(8):1158-64 [DOI] 10.1002/ps.3899. [PMID] 25185896.
2015
ROMK (Kir1.1) pharmacology comes of age.
Channels (Austin, Tex.). 9(3):119-20 [DOI] 10.1080/19336950.2015.1046733. [PMID] 25941772.
2014
Direct activation of β-cell KATP channels with a novel xanthine derivative.
Molecular pharmacology. 85(6):858-65 [DOI] 10.1124/mol.114.091884. [PMID] 24646456.
2014
Neurotoxicity and mode of action of N, N-diethyl-meta-toluamide (DEET).
PloS one. 9(8) [DOI] 10.1371/journal.pone.0103713. [PMID] 25101788.
2013
Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi.
Pesticide biochemistry and physiology. 106(3) [DOI] 10.1016/j.pestbp.2013.03.005. [PMID] 24187393.
2013
Insecticidal, repellent and fungicidal properties of novel trifluoromethylphenyl amides.
Pesticide biochemistry and physiology. 107(1):138-47 [DOI] 10.1016/j.pestbp.2013.06.006. [PMID] 25149248.
2013
Quinuclidine compounds differently act as agonists of Kenyon cell nicotinic acetylcholine receptors and induced distinct effect on insect ganglionic depolarizations.
Invertebrate neuroscience : IN. 13(2):167-77 [DOI] 10.1007/s10158-013-0160-2. [PMID] 23884575.

Grants

Sep 2023 ACTIVE
Multidisciplinary approaches toward new acaricide and repellent development: efficacy evaluation and elucidation of the modes of action
Role: Principal Investigator
Funding: US DEPT OF AG AG RES SVC
Sep 2023 ACTIVE
IUCRC Phase III University of Florida: Center for Arthropod Management Technologies (CAMTech)
Role: Co-Project Director/Principal Investigator
Funding: NATL SCIENCE FOU
May 2023 ACTIVE
Development of resistance-breaking aphicides with a novel mode- and mechanism- of action
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Mar 2023 ACTIVE
Physiological and toxicological relevance of potassium ion channels and reactive oxygen species with honey bee health
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Jan 2023 ACTIVE
Investigating the Impacts of Covert Virus Infection to Visual Pathways and Responses in the Honey Bee
Role: Principal Investigator
Funding: LSU AGCENTER via US DEPT OF AG NATL INST OF FOOD AND AG
Nov 2022 ACTIVE
Novel Ways to Plug the Bug: Unraveling the role of hemipteranKir channels in Feeding and plant pathogen transmission
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Nov 2022 – Mar 2024
Development of novel isoxazoline insecticides for control of arthropod vectors of human pathogens
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via BILL & MELINDA GATES FOUNDATION
Aug 2022 ACTIVE
Rickettsial Influence on Host Membrane Physiology in Arthropod Vectors
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 ACTIVE
CAMTech IUCRC Phase II Memberships
Role: Project Manager
Funding: MULTIPLE SPONSORS

Education

Postdoctoral Fellow
2015 · Vanderbilt University Medical Center
Ph.D.
2012 · University of Florida
M.S.
2009 · Virginia Tech
B.S.
2008 · Christopher Newport University

Contact Details

Phones:
Business:
(352) 273-9149
Emails:
Business:
dswale@ufl.edu
Addresses:
Business Mailing:
2055 MOWRY RD
GAINESVILLE FL 32610
Business Street:
Emerging Pathogens Institute
GAINESVILLE FL 32611